The History of the Plaque Assay

First Idea for Search "Plaque Assay Merits"

• Original Plaque Assay idea by Jerne (1963) - 3D Agar Gel
• Modified by Cunningham (1965) to make monolayer - < Link>
• Review paper by Jerne (1974) - Transplantation Reviews, Volume: 18, Date: 1974: the article on "Plaque forming cells: methodology and theory."  -  Author: Jerne, N Kat Page: 130 
  It is a Citation Classic <link >
• Original information about these papers from paper on "Production of Monolayer Plaque Assay Slides." (1981) < Link> Newman>
  
• Jerne Nobel Prize (1984) possibly for work on Immune System < link >

Next idea for Search "Improvements on Plaque Assay" (few links) / "Comparison of Virus Estimation Techniques" (some links on Google) / 
 - led to finding other methods

 - (keywords: PFU, plaque, TCID50, Vi-CELL )